{
  description = "Python flake with native packages";

  inputs = {
    nixpkgs.url = "github:NixOS/nixpkgs/nixos-23.11";
    nixpkgs-unstable.url = "github:NixOS/nixpkgs/nixos-unstable";
    flake-utils.url = "github:numtide/flake-utils";
  };

  outputs = { self, nixpkgs, nixpkgs-unstable, flake-utils}:
  flake-utils.lib.eachDefaultSystem (system:
  let
    pkgs = import nixpkgs {
      inherit system;
    };
    pkgs-unstable = import nixpkgs-unstable {
      inherit system;
      config.allowUnfree = true;
    };
    python-packages = p: with p; [
      biopython
      numpy
      dask
      numba
    ];
  in {
    devShells.default = pkgs.mkShell {
      packages = (with pkgs; [
        python311
        (python-packages python311Packages)
      ]) ++ (with pkgs-unstable; [
        nodejs
        memray

        # Editor of your choice
        # (jetbrains.plugins.addPlugins jetbrains.pycharm-professional [ "github-copilot" ])
        # vscodium
      ]);
    };
  });
}